Neuronal communication takes place by virtue of chemical signaling across the synapse. Diverse neurotransmitters are secreted from the presynaptic compartment in a regulated way, and activate specific receptors located at opposing postsynaptic membrane. Subsequently, clearance of these transmitters from the synaptic cleft determines the time and spatial shape of the synaptic response. Impairment of transsynaptic signaling at any level in this cascade may have pathological consequenses.

In this symposium, different regulatory events in synaptic transmission will be introduced. Distinguished investigators will treat the subject from the molecular to the organismal level, based on studies with animals and human material. Participation in this symposium will inform you about the current concepts in regulation of synaptic transmission.

Organization: Dr. Wim E.J.M. Ghijsen (UvA) en Dr. Loes H. Schrama (EKN)
 

09.30-10.10    Registration and coffee/tea
10.10-10.20    Opening by JEMF Leysen (President EKN)

                       Chairman: WEJM Ghijsen (University of Amsterdam)

10.20-11.05    PNE de Graan (University of Utrecht):
                       Glutamatergic transmission and PKC-mediated signal transduction in human focal epilepsy
11.05-11.50    BH Westerink (University of Groningen):
                       Extracellular transmitter levels in conscious animals
11.50-12.05    Coffee/tea
12.05-12.50    N Brose (Max-Planck Institute for Experimental Medicine, Göttingen):
                        Molecular mechanism of neurotransmitter release
12.50-13.30    Lunch
13.30-14.15    Poster session: Regulation of Synaptic Transmission (abstracts)

                     Chairman: BH Westerink

14.15-15.00   M Verhage (University of Utrecht):
                      The organisation of the active zone
15.00-15.45   WP De Potter (University of Antwerpen):
                      Transmitter release and dissection of the secretory cycle in sympathetic neurons
15.45-16.00   Coffee/tea

          17.00-18.00    Farewell drinks and snacks
 

Dr. W.E.J.M. Ghijsen Ph.D.
Institute of Neurobiology
Faculty of Biology
University of Amsterdam
Kruislaan 320, 1098-SM  Amsterdam
The Netherlands
Tel: (31) (0)20-525 7620
Fax: (31) (0)20-525 7709
e-mail: dr. WEJM Ghijsen
 

- EKN members   fl.45.=
- non-members     fl 70.=

To be paid at the meeting
 

Routebeschrijving:

Plaats: CWI gebouw, Kruislaan 413, 1098 SJ Amsterdam.

Met de auto:
Neem vanaf de rondweg Amsterdam A10 de afslag Diemen/Watergraafsmeer en rijdt richting Watergraafsmeer. Volg de Middenweg tot kruising met Kruislaan, en sla rechtsaf richting Jaap Eden baan/Science Park. Vervolg de Kruislaan onder het spoorviaduct, en neem tweede afslag links na het  spoorviaduct. Hier is het CWI, waar voldoende parkeergelegendheid is.

Met het openbaar vervoer:
Met de trein vanaf het Muiderpoortstation, neem daar bus 66 naar het CWI. Vanaf het Amstelstation, neem bus 15 tot Linnaeusparkweg, en stap daar over op bus 66 of vervolg te voet de Kruislaan onder het spoorviaduct door (zie verder autoroute).